The U.S. Food and Drug Administration (FDA) has granted breakthrough therapy designation to Ofev (nintedanib) as a potential therapy for progressive fibrosing interstitial lung disease (ILD) — which also affects systemic sclerosis patients — the treatment’s developer, Boehringer Ingelheim, has announced. Breakthrough therapy designation is given to investigational compounds that have preliminary clinical evidence showing their therapeutic potential on at least…
Read in Spanish The Costa Rican company Apuyantra S.A requested the registration of the terminology “CBD OIL” to be registered as its “international brand ...
Referral to specialized centers, focusing on skin lesions as well as joint and neurological manifestations, and treatment with corticosteroids and disease-modifying antirheumatic drugs (DMARDs), are among new expert recommendations for juvenile localized scleroderma. The study supporting those recommendations, “Consensus-based recommendations for the management of juvenile localized scleroderma,” was published in the journal Annals of the…
My cardiologist has given me the OK to go back to the gym. I’ve been waiting for his clearance for a long time. Working out at the gym was how I stayed healthy and in shape before being diagnosed with scleroderma. Since becoming ill, I have spent what seems like years in my recliner, medicated…
The first person has been enrolled in a clinical trial evaluating the investigational therapy bermekimab in adults with scleroderma, XBiotech, the developer of bermekimab, announced. Although the cause of scleroderma is unknown, the disease is thought to be at least partly driven by abnormally high levels of an inflammatory signaling molecule called interleukin-1 alpha (IL-1⍺). IL-1⍺…
Blocking the activity of estrogen may worsen skin fibrosis in people with scleroderma, according to a study in mice. Researchers from the Paris Descartes University, in France, believe that a lack of estrogen’s beneficial effects may help explain why scleroderma more commonly affects women after menopause — when the levels of this hormone decrease —…
Raynaud’s Association is launching several activities during October to raise awareness about Raynaud’s phenomenon, and help those affected by the condition. Either in its primary form, or linked to other illnesses such as scleroderma, Raynaud’s is characterized by discoloration of the fingers and toes, with reduced sensitivity and associated painful sensation. The condition is triggered…
It has been a long few weeks of dealing with recurrent benign paroxysmal positional vertigo while trying to maintain some sense of routine in between my need for sleep. While confined to bed, I’ve watched a lot of Netflix: mostly television series from decades ago — there’s nothing like returning to old favorites for cheering…
Read in Spanish In Potsdam, Germany, a group of 40 elderly patients with more than 80 years reduced their daily chronic pain when specialists ...
A modified version of the inflammatory protein TRAIL might be able to reverse fibrosis in scleroderma and related conditions, a study suggests. The study, titled “Targeting of dermal myofibroblasts through death receptor 5 arrests fibrosis in mouse models of scleroderma,” was published in the journal Nature Communications. TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) is a…